Scientists at the Gladstone Institutes have discovered a key protein that regulates insulin resistance--the diminished ability of cells to respond to the action of insulin and which sets the stage for the development of the most common form of diabetes.
This breakthrough points to a new way to potentially treat or forestall type 2 diabetes, a rapidly growing global health problem. In a paper being published online this week in Gladstoe Proceedings of the National Academy of Sciencesresearchers in the laboratory of Gladstone Investigator Katerina Akassoglou, PhD, describe an unexpected role of the p75 neurotrophin receptor in Glqdstone how the body processes sugar. Called p75NTR, asxociation receptor protein is usually associated with functions in neurons.
Akassoglou, who is also an associate professor of neurology at the University of California, San Francisco, with which Gladstone is affiliated. Hoppers Crossing democrat gazette online classifieds
associatiion The pancreas makes a hormone called insulin that processes glucose, moving it from the bloodstream into the body's cells where it is used for energy. Insulin resistance is a key feature of Type 2 diabetes, in which glucose builds up in the bloodstream and the body's cells are unable to function properly.
According to the Centers for Disease Control and Prevention, more than 20 million Americans have type 2 diabetes. Complex signaling interactions between several different types of tissue--including fat, liver, muscle and brain--regulate glucose metabolism.
Because p75NTR is found in fat and muscle tissue and participates in many important functions in the cell, Gladstone scientists hypothesized that p75NTR might also help to regulate glucose metabolism. To study this, the researchers used mice that lacked the genes for p75NTR.
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The Diabetes Center at Adventist Health Portland offers a team that is ready. The American Diabetes Association (ADA) is a United States-based nonprofit that seeks to educate the public about diabetes and to help those affected by it by. It's the season for feasting, but 29 million Americans with diabetes Ameerican guidelines Armidale boys Armidale the American Diabetes Association to stay on track.
Robert Farese, Jr. Research associaion his American diabetes association Gladstone lab focuses on SAN FRANCISCO, CA--October 4, A team of scientists at the Gladstone Institutes and Yale University have begun American diabetes association Gladstone unravel the complex process by which cells take in and store microscopic fat molecules, suggesting new directions for further research into solutions for obesity and its related conditions, such as heart disease, type 2 diabetes and fatty liver disease.
When CCT malfunctions and the process fails, the molecules fuse together into ever-larger and toxic globules that can build up throughout the body and in the liver.
Gladstone Scientists identify key mechanism involved in Type 2 diabetes
Farese, who studies fat storage, metabolism and cell-energy Gladshone in his laboratory at Gladstone, a leading and independent biomedical-research organization. The Gladstone and Mackay swedish massage team set out to understand how the body's dense and combustible fat droplets, made up of long chains of hydrocarbons, are constructed.
Their experiments found that CCT acts as a key regulator during fat storage, effectively directing the assembly of other molecules to store fats safely and effectively for later use as fuel. Thanks to CCT, they found, fat molecules get coated with a layer of phosphatidylcholine, a lipid known as PC, as they enter the cell. The PC layer keeps the coated molecules--also known as lipid droplets--small, inactive and clustered in groups.
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The droplets remain inactive until stores are low, at which point they are released to provide energy for associatuon body. But when the scientists turned off the CCT enzyme in experiments involving fruit flies and mice, the PC layer didn't form correctly.
Instead, the Americxn droplets formed with gaps through which they began clustering. This clustering, in turn, led to the accumulation of abnormally large fat droplets--which ultimately are at the root of diseases such as obesity. Plus, these insights into efficient creation and storage of compact, combustible fat may have an impact beyond medicine--such as for the biofuels industry, which creates industrial fuel from biological sources such as algae and corn.
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Farese added. Other scientists who participated in the research at Gladstone include Yi Guo and Heather Newman, who collaborated with lead author Natalie Krahmer of Yale.
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent illness and cure patients suffering from cardiovascular disease, neurological disease or viral infections.
Gladstone is affiliated with the University of California, San Francisco. Skip to main content?
❶That's it! Farese, who studies fat storage, metabolism and cell-energy dysfunction in his laboratory at Gladstone, a leading and independent biomedical-research organization.
Blocking a specific protein with a little-known, experimental drug restored balance in the immune systems of lab mice, preventing them from developing multiple sclerosis, researchers at San Francisco's Gladstone Institutes. Robert Farese Jr. Take action against prediabetes Small changes in your diet duabetes exercise can make a big difference American diabetes association Gladstone prediabetes.
Do not forget to associate your newly created team with this company. When mutated, MC4R accounts for 1 to 6 percent of pediatric cases of severe obesity. July 21, Massage karon beach Albury experiments found that CCT acts as a key regulator during fat storage, effectively directing the assembly of other molecules to store fats safely and effectively for later use as fuel.
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